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Hans Lehrach Selected Research

Ataxin-2

1/2012FOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression.
1/2012Ataxin-2-like is a regulator of stress granules and processing bodies.
4/2007Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
10/2005Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
2/2005An integrative approach to gain insights into the cellular function of human ataxin-2.

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Hans Lehrach Research Topics

Disease

39Neoplasms (Cancer)
01/2023 - 04/2006
6Colonic Neoplasms (Colon Cancer)
11/2021 - 12/2010
5Colorectal Neoplasms (Colorectal Cancer)
01/2023 - 10/2011
5Spinocerebellar Ataxias (Spinocerebellar Ataxia)
01/2012 - 02/2005
4Carcinoma (Carcinomatosis)
02/2023 - 05/2007
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2012 - 02/2005
3Medulloblastoma
02/2016 - 08/2012
3Prostatic Neoplasms (Prostate Cancer)
02/2013 - 09/2011
2Macular Degeneration (Age-Related Maculopathy)
04/2024 - 06/2023
2Basal Cell Carcinoma (Rodent Ulcer)
12/2018 - 01/2013
2Fatty Liver
11/2015 - 01/2014
2Carcinogenesis
06/2014 - 05/2011
2Inflammation (Inflammations)
01/2014 - 06/2011
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2011 - 08/2005
2Down Syndrome (Down's Syndrome)
06/2006 - 02/2006
2Metrorrhagia (Spotting)
05/2004 - 09/2003
1Cicatrix (Scar)
04/2024
1Hemorrhage
04/2024
1Choroidal Neovascularization
04/2024
1COVID-19
09/2022
1Coinfection
09/2022
1Proteostasis Deficiencies
01/2019
1Hemolytic Anemia
01/2019
1Inborn Genetic Diseases (Disease, Hereditary)
01/2019
1Leukemia
01/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2018
1Sepsis (Septicemia)
01/2017
1Stomach Neoplasms (Stomach Cancer)
02/2016
1Tonsillar Neoplasms
02/2015
1Breast Neoplasms (Breast Cancer)
05/2014
1Ataxia Telangiectasia (Louis Bar Syndrome)
05/2014
1Melanoma (Melanoma, Malignant)
01/2014
1Fibrosis (Cirrhosis)
01/2014
1Non-alcoholic Fatty Liver Disease
01/2014
1Astrocytoma (Pilocytic Astrocytoma)
08/2013

Drug/Important Bio-Agent (IBA)

17Proteins (Proteins, Gene)FDA Link
11/2017 - 12/2002
6MicroRNAs (MicroRNA)IBA
06/2014 - 09/2009
5Biomarkers (Surrogate Marker)IBA
01/2018 - 02/2011
5DNA (Deoxyribonucleic Acid)IBA
01/2017 - 01/2009
5Ataxin-2IBA
01/2012 - 02/2005
4RNA (Ribonucleic Acid)IBA
09/2022 - 08/2012
4Messenger RNA (mRNA)IBA
11/2017 - 01/2013
4Phosphotransferases (Kinase)IBA
05/2014 - 12/2010
4polyglutamineIBA
04/2007 - 12/2002
3Fluorouracil (Carac)FDA LinkGeneric
01/2023 - 06/2014
3EnzymesIBA
01/2019 - 02/2006
3ChromatinIBA
02/2016 - 04/2010
3Transcription Factors (Transcription Factor)IBA
05/2014 - 05/2007
3ErbB Receptors (EGF Receptor)IBA
01/2013 - 01/2012
3AutoantibodiesIBA
01/2006 - 03/2005
2Peptide Initiation Factors (Initiation Factor)IBA
02/2023 - 11/2017
2Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2023 - 11/2021
2Drug CombinationsIBA
11/2021 - 12/2018
2Cisplatin (Platino)FDA LinkGeneric
01/2018 - 02/2015
2Epidermal Growth Factor (EGF)IBA
01/2013 - 08/2012
2MethyltransferasesIBA
01/2013 - 01/2013
2Pyruvate KinaseIBA
11/2012 - 05/2011
2RNA Splicing FactorsIBA
01/2012 - 06/2011
2ParaffinIBA
09/2011 - 01/2009
2Formaldehyde (Formol)FDA Link
09/2011 - 01/2009
2NucleotidesIBA
09/2011 - 12/2010
2Complementary DNA (cDNA)IBA
09/2005 - 08/2005
2AutoantigensIBA
09/2005 - 03/2005
1Sweetening Agents (Sweeteners)IBA
04/2024
1SaccharinIBA
04/2024
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2024
1ProteomeIBA
06/2023
1AZD 6244IBA
01/2023
1regorafenibIBA
01/2023
1Gefitinib (Iressa)FDA Link
01/2023
1Bevacizumab (Avastin)FDA Link
11/2021
1Irinotecan (Camptosar)FDA LinkGeneric
11/2021
1Cetuximab (Erbitux)FDA Link
11/2021
1Triose-Phosphate Isomerase (Triosephosphate Isomerase)IBA
01/2019
1Interleukin-6 (Interleukin 6)IBA
12/2018
1Carboplatin (JM8)FDA LinkGeneric
01/2018
1HLA-A*02:01 antigenIBA
01/2018
1PlatinumIBA
01/2018
1Aldehyde DehydrogenaseIBA
12/2017
1Annexin A1IBA
02/2016
1Protein CIBA
01/2016
1src-Family KinasesIBA
01/2016
1Oncogene Proteins (Oncogene Protein)IBA
01/2016
1Fatty Acids (Saturated Fatty Acids)IBA
11/2015
1AntimetabolitesIBA
06/2014
1Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA
01/2014
1LipidsIBA
01/2014
1Small Interfering RNA (siRNA)IBA
01/2014
1Adapalene (Differin)FDA LinkGeneric
01/2014
13,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA
01/2014
1Mitogen-Activated Protein KinasesIBA
08/2013

Therapy/Procedure

10Therapeutics
01/2023 - 01/2009
3Drug Therapy (Chemotherapy)
11/2021 - 02/2015
2Precision Medicine
01/2017 - 09/2014
2Ligation
12/2011 - 10/2011
1Lasers (Laser)
04/2024
1Surgical Instruments (Clip)
01/2023
1Immunotherapy
01/2018
1Heterologous Transplantation (Xenotransplantation)
12/2017
1Resuscitation
01/2017